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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and physical exercise.

Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err to the side of caution and let the FDA do its job and demand some investigation be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on his or her medications.

Researchers found out that participants taking this drug for a year, lost weight within one month and have kept the weight off throughout the 56 weeks from the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them more effective and safer.

Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that since right now there are not any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and pulse rate, and must not be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure level, in addition to by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed in the liver after that uptake from your intestines and has no therapeutic effect. Buprenorphine is the active substance; it can be absorbed within the tongue (and through the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I in addition have treated addicts who've had gastric bypass, the place that the first section of the intestine is bypassed along with the stomach contents empty right into a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy in which the drug is taken up through the duodenum and transferred straight to the liver from the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken on by servings of the intestine which are not served from the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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